Precursor Cell Transitions in Oligodendrocyte Development

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Precursor Cell Transitions in Oligodendrocyte Development

Address correspondence to Mark Noble, Huntsman Cancer Institute, Rm. 4280, Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112. Tel.: (801) 585-7167. Fax: (801) 585-7120. E-mail: [email protected] The physiological demands made upon precursor cell populations during different developmental epochs can be remarkably divergent, particularly in tissues that do not...

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Catalpol induces oligodendrocyte precursor cell-mediated remyelination in vitro.

In demyelinating diseases such as multiple sclerosis, one of the treatment strategies includes remyelination using oligodendrocyte precursor cells (OPC). Catalpol, the extract of radix rehmanniae, is neuroprotective. Using an OPC culture model, we showed that 10 μM catalpol promotes OPC proliferation, cell migration and differentiation into mature oligodendrocytes. The 10 μM catalpol displayed ...

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Intracellular signaling mechanisms directing oligodendrocyte precursor cell migration.

of an adult wild-type mouse that received a homotopic graft of subventricular zone cells from a GFP /TrkB / mouse and was killed 15 d later. Graft-derived neurons (green) migrate to the olfactory bulb, disperse radially into several olfactory bulb layers (granular layer shown in picture; red, DAPI nuclear dye), and extend dendrites even in the absence of the neurotrophin receptor TrkB. For more...

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Diazoxide Promotes Oligodendrocyte Precursor Cell Proliferation and Myelination

BACKGROUND Several clinical conditions are associated with white matter injury, including periventricular white matter injury (PWMI), which is a form of brain injury sustained by preterm infants. It has been suggested that white matter injury in this condition is due to altered oligodendrocyte (OL) development or death, resulting in OL loss and hypomyelination. At present drugs are not availabl...

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Demyelination in the adult CNS can be followed by extensive repair. However, in multiple sclerosis, the differentiation of oligodendrocyte lineage cells present in demyelinated lesions is often inhibited by unknown factors. In this study, we test whether myelin debris, a feature of demyelinated lesions and an in vitro inhibitor of oligodendrocyte precursor differentiation, affects remyelination...

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ژورنال

عنوان ژورنال: Journal of Cell Biology

سال: 2000

ISSN: 0021-9525,1540-8140

DOI: 10.1083/jcb.148.5.839